Abzena, Angiex Collaborate for Phase I Trial of Solid Cancer Tumor Therapy

09 August 2024

Angiex Partners with Abzena for Phase I Trial of AGX101 Solid Tumor Therapy

Angiex has partnered with Abzena to advance the Phase I trial of AGX101, a novel TM4SF1-targeted antibody-drug conjugate (ADC) designed to treat solid tumors by targeting the blood vessels that supply them. This collaboration with Abzena, known for its expertise in biopharmaceutical manufacturing, is a critical component in ensuring the success of the early-stage clinical trial, as Angiex works to bring this innovative cancer therapy to patients with aggressive solid tumors.

PharmTech covered the collaboration, emphasizing the importance of strategic partnerships in clinical development. A highly regarded source for pharmaceutical manufacturing and development news, PharmTech highlighted how collaborations between biotech companies and CDMOs like Abzena are vital for pushing the boundaries of oncology research. Their coverage underscores the potential of AGX101 to make a significant impact in the treatment of solid tumors.


About Angiex

Angiex Inc. is a privately held biotech startup whose mission is to exploit newly discovered biological transport mechanisms to make drugs with revolutionary power over cancer. Based in Cambridge, Mass., Angiex was founded by a scientific team of leading experts in angiogenesis, vascular biology, and oncology. The company is developing a novel portfolio of Nuclear-Delivered Antibody-Drug Conjugates™ (ND-ADCs) that release therapeutic payloads directly into the nucleus or cytosol, where the site of payload action is located. This direct delivery holds the promise of enhancing the efficacy and therapeutic margin of conventional ADCs. The lead product, AGX101, has advanced through pre-clinical development and is about to begin Phase 1 clinical trials. To learn more about Angiex...