North American Biotech Innovation: Who and Where?

07 October 2024

Angiex Featured as a North American Biotech Leader in Drug Discovery World

Angiex has been recognized in Drug Discovery World as one of North America's most innovative biotech companies, spotlighted for its pioneering work on nuclear-delivered antibody-drug conjugates (ND-ADCs) and TM4SF1-directed therapies targeting solid tumors. The article highlights Angiex’s recent milestone of dosing the first patient in its Phase I clinical trial for AGX101, a first-in-class ADC targeting tumor blood vessels.

In the feature, Angiex’s CEO and Founder, Paul Jaminet, emphasized how Cambridge’s biotech infrastructure was instrumental in the company’s launch. “For entrepreneurs, the advantage of having ready access to expertise, capital, and a company incubation ecosystem is hard to overstate," Jaminet noted. "In our early years, we had limited funding and had to be very capital efficient, and having the resources of an incubator and the ability to share lab space was immensely helpful.” The support of LabCentral, located near MIT, played a pivotal role in Angiex’s early development, allowing the company to innovate and grow efficiently.

Drug Discovery World continues to highlight key biotech players driving innovation, and Angiex’s focus on groundbreaking cancer therapies underscores its leadership in advancing the future of oncology.


About Angiex

Angiex Inc. is a privately held biotech startup whose mission is to exploit newly discovered biological transport mechanisms to make drugs with revolutionary power over cancer. Based in Cambridge, Mass., Angiex was founded by a scientific team of leading experts in angiogenesis, vascular biology, and oncology. The company is developing a novel portfolio of Nuclear-Delivered Antibody-Drug Conjugates™ (ND-ADCs) that release therapeutic payloads directly into the nucleus or cytosol, where the site of payload action is located. This direct delivery holds the promise of enhancing the efficacy and therapeutic margin of conventional ADCs. The lead product, AGX101, has advanced through pre-clinical development and is about to begin Phase 1 clinical trials. To learn more about Angiex...