Millipore-Sigma collaborates with Angiex

28 August 2017

Millipore-Sigma Collaborates with Angiex to Speed Clinical Readiness of New Cancer Therapy

  • Project is first for MilliporeSigma’s Massachusetts BioReliance® End-to-End Solutions center
  • Collaboration gives Angiex access to MilliporeSigma’s processdevelopment tools and technologies

Billerica, Massachusetts, August 29, 2017 – MilliporeSigma today announced a new collaboration with Angiex, Inc., Cambridge, Massachusetts, to support the biotechnology start-up’s ability to speed its lead oncology antibody drug candidate to clinical use. Angiex is developing an antibody-drug conjugate (ADC) therapy for cancer against a vascular target, TM4SF1.

The collaboration with Angiex is the first project to be undertaken at MilliporeSigma’s biodevelopment center in Massachusetts. MilliporeSigma will give Angiex access to end-to-end process development tools, education programs and training to support its success.

“Companies benefit from our expertise and experience in developing GMP manufacturing processes for early clinical development programs,” said Udit Batra, CEO, MilliporeSigma. “With an end-to-end approach, MilliporeSigma can facilitate and accelerate scaling and technical transfer for companies like Angiex.”

Angiex CEO Dr. Paul Jaminet applauded MilliporeSigma’s broad range of process development capabilities and services for customers at all stages of molecule development and commercialization. “Through this collaboration, Angiex hopes to accelerate our path to the clinic. We appreciate MilliporeSigma’s expertise in bringing to cancer patients an innovative treatment capable of addressing the most dangerous solid tumors,” Jaminet said.

MilliporeSigma’s BioReliance® End-to-End Solutions delivers products and services allowing biopharmaceutical companies to accelerate the progression of potential new therapies from the laboratory into clinical trial and on toward commercialization. The turnkey package includes process development, cGMP manufacturing, facility design, equipment for pilot-plant production, process and equipment training, technology transfer, equipment qualification and set-up for commercialization. To further support its global BioReliance® End-to-End Solutions, MilliporeSigma will inaugurate its new biodevelopment center in Burlington, Massachusetts, in October 2017.

MilliporeSigma’s BioReliance® End-to-End Solutions is part of the Process Solutions business area within the Life Science business.

About Angiex

Angiex Inc. is a privately held biotech startup whose mission is to exploit newly discovered biological transport mechanisms to make drugs with revolutionary power over cancer. Based in Cambridge, Mass., Angiex was founded by a scientific team of leading experts in angiogenesis, vascular biology, and oncology. The company is developing a novel portfolio of Nuclear-Delivered Antibody-Drug Conjugates™ (ND-ADCs) that release therapeutic payloads directly into the nucleus or cytosol, where the site of payload action is located. This direct delivery holds the promise of enhancing the efficacy and therapeutic margin of conventional ADCs. The lead product, AGX101, has advanced through pre-clinical development and is about to begin Phase 1 clinical trials. To learn more about Angiex...