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Exploiting novel biology to gain revolutionary power over cancer

Angiex is developing first-in-class Nuclear-Delivered Antibody-Drug ConjugatesTM (ND-ADCs) to address the hallmarks of cancer lethality

How Cancer Kills: the Hallmarks of Lethality

Cancers are distinguished from normal tissue by a number of hallmarks. Many of these hallmarks are shared by both benign and malignant cancers, but some are found only in malignant cancers capable of killing. Three hallmarks above all contribute to cancer lethality:

  1. Angiogenesis — the growth of new blood vessels — enables tumors to grow without limit.
  2. Invasion and Metastasis – the migration of tumor cells through normal tissue and their spread throughout the body – accounts for most cancer deaths.
  3. Suppression of Immune Defense – so that the immune system fails to detect cancer cells and eliminate them – is cancer’s way of beating our last line of natural defense.

TM4SF1 and Threefold Power Over Lethality

Angiex founders discovered the special biology of the intracellular transporter TM4SF1. TM4SF1 is normally specific to endothelial cells (the cells lining the walls of blood vessels) where it enables new blood vessels to grow. But TM4SF1 is commonly turned on by malignant cancer cells because it enables them to invade and metastasize.

TM4SF1 is widely and highly expressed in the tumor cells of most solid cancers and in the endothelial cells of angiogenic tumor blood vessels. Drugs directed to TM4SF1 can therefore attack both Angiogenesis and Invasion and Metastasis. Moreover, because the endothelium controls immune cell trafficking into tumors, TM4SF1-directed drugs can potentially overcome cancer’s Suppression of Immune Defense.

TM4SF1 has another special feature: it internalizes from the cell surface to the nucleus. This is a gift to drug-makers: TM4SF1-directed antibody can carry conjugated drug payloads inside tumor cells to their most sensitive and protected compartment.

Angiex Nuclear-Delivered Antibody-Drug Conjugates™: No One Should Die of Cancer

Angiex’s mission is to exploit the biology of TM4SF1 to make new drugs – Nuclear-Delivered Antibody-Drug ConjugatesTM (ND-ADCs) – that specifically find tumor cells and tumor vascular endothelial cells and deliver conjugated drug payloads that destroy cancers or deprive them of their hallmarks of lethality.

Angiex believes that No One Should Die of Cancer. Angiex’s lead drug, now entering the clinic, AGX101, is our first step toward fulfilling that promise.